Ji, Kegong published the artcileGold-catalyzed regioselective oxidation of propargylic carboxylates: a reliable access to ¦Á-carboxy-¦Á,¦Â-unsaturated ketones/aldehydes, Application In Synthesis of 1237588-12-3, the publication is Beilstein Journal of Organic Chemistry (2013), 1925-1930, 6 pp., database is CAplus and MEDLINE.
Gold-catalyzed intermol. oxidation of carboxylates of primary or secondary propargylic alcs. are realized with excellent regioselectivity, which is ascribed to inductive polarization of the C-C triple bond by the electron-withdrawing carboxy group. The gold carbene intermediates thus generated undergo selective 1,2-acyloxy migration over a 1,2-C-H insertion, and the selectivities could be dramatically improved using a P,S-bidentate ligand, which is proposed to enable the formation of tris-coordinated and hence less electrophilic gold carbene species. ¦Á-Carboxy ¦Á,¦Â-unsaturated ketones/aldehydes can be obtained with fair to excellent yields.
Beilstein Journal of Organic Chemistry published new progress about 1237588-12-3. 1237588-12-3 belongs to catalysis-chemistry, auxiliary class Mono-phosphine Ligands, name is 4-(2-(Di(adamantan-1-yl)phosphino)phenyl)morpholine, and the molecular formula is C30H42NOP, Application In Synthesis of 1237588-12-3.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia