Sigfridsson, Kalle published the artcilePreformulation investigation and challenges; salt formation, salt disproportionation and hepatic recirculation, Name: N1,N2-Dibenzylethane-1,2-diamine, the publication is European Journal of Pharmaceutical Sciences (2017), 262-272, database is CAplus and MEDLINE.
A compound, which is a selective peroxisome proliferator activated receptor (PPAR) agonist, was investigated. The aim of the presented studies was to evaluate the potential of the further development of the compound Fundamental physicochem. properties and stability of the compound were characterized in solution by liquid chromatog. and NMR and in solid-state by various techniques. The drug itself is a lipophilic acid with tendency to form aggregates in solution The neutral form was only obtained in amorphous form with a glass-transition temperature of approx. 0¡ãC. The intrinsic solubility at room temperature was determined to 0.03 mg/mL. Chem. stability studies of the compound in aqueous solutions showed good stability for at least two weeks at room temperature, except at pH 1, where a slight degradation was already observed after one day. The chem. stability in the amorphous solid-state was investigated during a period of three months. At 25¡ãC/60% relative humidity (RH) and 40¡ãC/75% RH no significant degradation was observed At 80¡ãC, however, some degradation was observed after four weeks and approx. 3% after three months. In an accelerated photostability study, degradation of approx. 4% was observed Attempts to identify a crystalline form of the neutral compound were unsuccessful, however, salt formation with tert-butylamine, resulted in crystalline material. Results from stability tests of the presented crystalline salt form indicated improved chem. stability at conditions whereas the amorphous neutral form degraded.
European Journal of Pharmaceutical Sciences published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C17H29BO2, Name: N1,N2-Dibenzylethane-1,2-diamine.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia