Hedvati, Lilach published the artcileCinnamic acid derived oxazolinium ions as novel cytotoxic agents, Synthetic Route of 16909-09-4, the publication is European Journal of Medicinal Chemistry (2002), 37(7), 607-616, database is CAplus and MEDLINE.
Substituted cinnamoyl chlorides were converted into (2-hydroxyethyl)oxazolinium chlorides (I), N,N-bis-(2-chloroethyl)amides, and (2-chloroethyl)oxazolinium chlorides. Although I which possess electron-donating substituents (Me or MeO) were more potent than those substituted by electron-withdrawing groups (NO2, Cl or CF3), the difference in cytotoxic action was not significant. Modification of the lipophilic character in a series of alkoxy-substituted I led to more active compounds, the octyloxyphenyl derivative II being the most potent and displaying cytotoxic activity in the ¦ÌM range. It is assumed that the oxazolinium salts act as alkylating agents, and undergo nucleophilic attack on the methylene adjacent to the ring oxygen where the oxazolinium ring parallels the aziridinium ring intermediate found in classical alkylating agents.
European Journal of Medicinal Chemistry published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Synthetic Route of 16909-09-4.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia