Takeda, Shuichi published the artcileMetabolic fate of triethylenetetramine dihydrochloride (trientine hydrochloride, TJA-250) 2. Metabolism study in rats using 14C-TJA-250, SDS of cas: 38260-01-4, the publication is Oyo Yakuri (1995), 49(2), 173-8, database is CAplus.
The metabolites of triethylenetetramine dihydrochloride (TJA-250) in urine, feces, liver, kidney, and plasma were studied in rats after i.v. or oral administration of 14C-TJA-250. By both administration routes, the metabolite M-1, which is 1-acetamido-8-amino-3,6-di-azaoctane (acetylated metabolite), was isolated from urine, liver, kidney and plasma. No metabolites were found in feces after oral administration. This observation is supported by the finding that 14C-TJA-250 was not decomposed in the intestinal microflora in vitro. When 14C-TJA-250 was incubated at 37 ¡ãC with the whole homogenates of liver, kidney and small intestine, some metabolites including M-1 were generated by small intestine. M-1 was also produced by the S-9 mixture of liver and kidney plus acetyl CoA. These results suggested that TJA-250 is excreted mainly in urine after biotransformation including acetyl conjugation.
Oyo Yakuri published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C14H26O2, SDS of cas: 38260-01-4.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia