Jadhav, Nikhil C. published the artcileDesign, synthesis and molecular docking study of novel pyrrole-based ¦Á-amylase and ¦Á-glucosidase inhibitors, Product Details of C10H11NO4, the publication is Medicinal Chemistry Research (2017), 26(10), 2675-2691, database is CAplus.
In an effort to design and synthesize a new class of ¦Á-glucosidase and ¦Á-amylase inhibitors, we have synthesized novel pyrrole based mols. using mol. hybridization approach. These novel analogs were synthesized by the novel methodol. developed in our lab which comprises of the multi-component direct synthesis route using hypervalent iodine reagent. The compounds were characterized by IR, 1H NMR (NMR), 13C NMR and Mass Spectroscopy. These compounds were screened for their ¦Á-amylase and ¦Á- glucosidase activity. They showed a varying degree of inhibition with IC50 values ranging between 0.4 to 4.14 ¦Ìmol/mL and 0.8 to 4.14 ¦Ìmol/mL for ¦Á-amylase and ¦Á-glucosidase resp. Compounds 3, 7, 12, and 18 showed excellent activity as compared to standard acarbose. This has identified a new class of ¦Á-amylase and ¦Á-glucosidase inhibitor which can be further developed as antihyperglycemic agents. The mol. docking anal. was carried out to better understand of interaction between ¦Á-amylase and ¦Á-glucosidase target and inhibitors in this series. We also generated a homol. model for human ¦Á-glucosidase enzyme and identified the key residues at the binding site. The outcome of the study could be used for the rational design of potent and selective ¦Á-amylase and ¦Á-glucosidase inhibitors, resp.
Medicinal Chemistry Research published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Product Details of C10H11NO4.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia