Zarudnitskii, E. V. published the artcileC-phosphorylation of 2-dialkylaminothiazole and imidazo[2,1-b]thiazole derivatives, Recommanded Product: 1,1-Dimethylthiourea, the publication is Ukrainskii Khimicheskii Zhurnal (Russian Edition) (2002), 68(11-12), 38-42, database is CAplus.
Phosphorylation of 2-dialkylaminothiazole derivatives with PCl3, Ph2PCl and Ph2PBr was studied. Reaction of 2-diethylaminothiazole with R2PCl gave 2-Et2N-5-PR2(C3HNS) (2 R = Cl, 3 R = Ph). Phosphination of Et 2-diethylaminothiazolecarboxylate (4) with Ph2PBr gave 5-PPh2 derivative (5), which was hydrolyzed to free acid (6). Thiazoleacetates 2-R2N(C3HNS)-4-CH2COOEt were also phosphinated in position 5 to give 2-R2N(C3NS)-4-CH2COOEt-5-PPh2 (8a–c, R = Me, Et, or R2N = morpholino), which were hydrolyzed to free acids (9a–c). In contrast to esters of 2-dialkylamino-4-thiazoleacetic acids, Et ester of 6-imidazo[2,1-b]thiazoleacetic acid undergoes C-phosphination with Ph2PCl both at heterocycle and at methylene group.
Ukrainskii Khimicheskii Zhurnal (Russian Edition) published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C7H11N, Recommanded Product: 1,1-Dimethylthiourea.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia