Drasar, Pavel published the artcileSteroids. Part CCCXLVII. Synthesis and in vitro antimetabolic evaluation of some steroidal thiazoles, Synthetic Route of 6972-05-0, the publication is Collection of Czechoslovak Chemical Communications (1989), 54(12), 3339-47, database is CAplus.
Steroidal thiazoles I (R = NH2, NHMe, NHPh, NMe2, Ph, Me, CH2CO2Me) have been synthesized. The starting bromo ketone II (R1 = Br) was prepared by bromination of pregnen-20-ones II (R1 = H) with copper (II) bromide, and was used for synthesis of the thiazole derivatives employing the Hantzsch reaction. Preliminary biol. evaluation of thiazoles I and III against the P388 lymphocytic leukemia cell showed growth inhibition values of ED50 2.9 and 7 ¦Ìg/mL for thiazoles III and I (R = NH2), resp. Other I were less active.
Collection of Czechoslovak Chemical Communications published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, Synthetic Route of 6972-05-0.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia