Legnani, Luca published the artcileEfficient access to unprotected primary amines by iron-catalyzed aminochlorination of alkenes, Application of O-Pivaloylhydroxylamine trifluoromethanesulfonate, the publication is Science (Washington, DC, United States) (2018), 362(6413), 434-439, database is CAplus and MEDLINE.
Primary amines are essential constituents of biol. active mols. and versatile intermediates in the synthesis of drugs and agrochems. However, their preparation from easily accessible alkenes remains challenging. Here, the authors report a general strategy to access primary amines from alkenes through an operationally simple iron-catalyzed aminochlorination reaction. A stable hydroxylamine derivative and benign sodium chloride act as the resp. nitrogen and chlorine sources. The reaction proceeds at room temperature under air; tolerates a large scope of aliphatic and conjugated alkenes, including densely functionalized substrates; and provides excellent anti-Markovnikov regioselectivity with respect to the amino group. The reactivity of the 2-chloroalkylamine products, an understudied class of amphoteric mols., enables facile access to linear or branched aliphatic amines, aziridines, aminonitriles, azido amines, and homoallylic amines.
Science (Washington, DC, United States) published new progress about 1293990-73-4. 1293990-73-4 belongs to catalysis-chemistry, auxiliary class Aliphatic Chain, name is O-Pivaloylhydroxylamine trifluoromethanesulfonate, and the molecular formula is C6H12F3NO5S, Application of O-Pivaloylhydroxylamine trifluoromethanesulfonate.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia