de Silva, Nilamuni H.’s team published research in Bioorganic Chemistry in 114 | CAS: 4230-93-7

Bioorganic Chemistry published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Synthetic Route of 4230-93-7.

de Silva, Nilamuni H. published the artcileMicrowave-assisted rapid synthesis of spirooxindole-pyrrolizidine analogues and their activity as anti-amyloidogenic agents, Synthetic Route of 4230-93-7, the publication is Bioorganic Chemistry (2021), 105128, database is CAplus and MEDLINE.

A library of Sox-pyrrolizidines was rapidly prepared by microwave-assisted, one-pot, three-component, 1,3-dipolar cycloaddition of azomethine ylides from L-proline and isatin, with various ¦Â-nitrostyrenes. Nitro-Sox compounds, I, 4d and 4e inhibit HEWL amyloid fibril formation by ThT studies with percentages of fluorescence intensity of 55.4, 42.9 and 40.3%, resp. Further studies with MTT assay, Raman spectroscopy, TEM and mol. docking supported these promising candidates for activity against amyloid misfolding, a phenomenon leading to Alzheimer’s disease pathol.

Bioorganic Chemistry published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Synthetic Route of 4230-93-7.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia