Li, Yu-Lei published the artcileComparison of different strategies towards the chemical synthesis of long-chain scorpion toxin AaH-II, Recommanded Product: Fmoc-Pro-OH, the publication is Journal of Peptide Science (2022), 28(2), e3365, database is CAplus and MEDLINE.
Long-chain scorpion toxin AaH-II isolated from Androctonus australis Hector can selectively inhibit mammalian voltage-gated sodium ion channel Nav1.7 responsible for pain sensation. Efficient chem. synthesis of AaH-II and its derivatives is beneficial to the study of the function and mechanism of Nav1.7 and the development of potential peptide inhibitors. Herein, we compared three different strategies, namely, direct solid-phase peptide synthesis, hydrazide-based two-segment native chem. ligation, and hydrazide-based three-segment native chem. ligation for the synthesis of AaH-II. The hydrazide-based two-segment native chem. ligation affords the target toxin with the optimal efficiency, which provides a practically robust procedure for the preparation of tool mols. derived from AaH-II to study the biol. functions and modulation of Nav1.7. Our work highlights the importance of selecting suitable segment condensation approach in the chem. synthesis of protein toxins.
Journal of Peptide Science published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C20H19NO4, Recommanded Product: Fmoc-Pro-OH.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia