Wangler, Bjorn published the artcileKit-Like 18F-Labeling of Proteins: Synthesis of 4-(Di-tert-butyl[18F]fluorosilyl)benzenethiol (Si[18F]FA-SH) Labeled Rat Serum Albumin for Blood Pool Imaging with PET, Category: catalysis-chemistry, the publication is Bioconjugate Chemistry (2009), 20(2), 317-321, database is CAplus and MEDLINE.
Radiosyntheses of 18F-radiopharmaceuticals for positron emission tomog. (PET) normally require an extraordinarily high effort of tech. equipment and specially trained personnel. We recently reported a novel method for the introduction of fluorine-18 into peptides for PET-imaging based on silicon-18F-chem. (SiFA technique). We herewith introduce the first SiFA-based Kit-like radio-fluorination of a protein (rat serum albumin, RSA) and demonstrate its usefulness for in vivo imaging with ¦ÌPET in normal rats as well as in a rat heterotropic transplanted heart model. As a labeling agent, we prepared 4-(di-tert-butyl[18F]fluorosilyl)benzenethiol (Si[18F]FA-SH) by simple isotopic exchange in 40-60% radiochem. yield (RCY) and coupled it directly to a Sulfo-SMCC derivatized RSA in an overall RCY of 12% within 20-30 min. The tech. simple labeling procedure does not require any elaborated purification procedures and is a straightforward example of a successful application of Si-18F chem. for in vivo imaging with PET.
Bioconjugate Chemistry published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C18H28N2O7, Category: catalysis-chemistry.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia