Bhaskararao, Munukoti published the artcileOne-pot ultrasonication assisted synthesis of biologically active 1,3,4-oxadiazole derivatives catalyzed by TiO2 nanoparticles, COA of Formula: C8H8O2, the publication is Research Journal of Chemistry and Environment (2022), 26(5), 168-176, database is CAplus.
A novel approach was adopted in the one-pot synthesis of 2-phenyl-5-aryl substituted-1,3,4-oxadiazole derivatives I (R = Ph, 3-methylphenyl, 2-naphthyl, etc.) through ultrasonication. Substituted carboxylic acids RCOOH underwent condensation with benzohydrazide in the presence of ortho-(benzotriazol-1-yl)-N,N,N’,N’-tetramethyluronium tetrafluoroborate (TBTU) to form diacylhydrazine derivatives PhC(O)NHNH(O)R. In the next step, the diacylhydrazine derivatives were subjected to cyclodehydration in the presence of titanium dioxide (TiO2) nanoparticles (NPs) in the presence of dichloromethane (DCM) solvent, at room temperature through which excellent pure yields of substituted 1,3,4-oxadiazoles I were obtained. The reaction scheme was also performed with other metal oxides NPs (CuO, ZnO, NiO) and the results have shown that TiO2 NPs were most effective in forming the best yields of the derivatives Their biol. applicability was investigated by conducting anti-bacterial studies against gram-neg. Escherichia coli and gram-pos. Staphylococcus aurues. In these studies, almost majority of the derivatives have shown pos. results in deactivating the micro-organisms.
Research Journal of Chemistry and Environment published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C8H8O2, COA of Formula: C8H8O2.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia