Otero, Elver published the artcileSynthesis and leishmanicidal activity of cinnamic acid esters: structure-activity relationship, Computed Properties of 16909-09-4, the publication is Medicinal Chemistry Research (2014), 23(3), 1378-1386, database is CAplus.
Several cinnamic acid esters were obtained via Fischer esterification of cinnamic acids derivatives with aliphatic alcs. Structures of the products were elucidated by spectroscopic anal. The synthesized compounds were evaluated for antileishmanial activity against L. (V) panamensis amastigotes and cytotoxic activity was evaluated against mammalian U-937 cells. The compounds 11, 15-17, and 23, were active against Leishmania parasite and although toxic for mammalian cells, they still are potential candidates for antileishmanial drug development. A SAR anal. indicates that first, while smaller alkyl chains lead to higher selectivity indexes (10, 11 vs. 12-17); second, the degree of oxygenation is essential for activity, primarily in positions 3 and 4 (17 vs. 18-20 and 22); and third, hydroxyl groups increase both activity and cytotoxicity (14 vs. 23). On the other hand, the presence of a double bond in the side chain is crucial for cytotoxicity and leishmanicidal activity (12 vs. 21). However, further studies are required to optimize the structure of the promising mols. and to validate the in vitro activity against Leishmania demonstrated here with in vivo studies.
Medicinal Chemistry Research published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Computed Properties of 16909-09-4.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia