Conway, John H. published the artcileRegiodivergent Iridium(III)-Catalyzed Diamination of Alkenyl Amides with Secondary Amines: Complementary Access to ¦Ã- or ¦Ä-Lactams, Safety of O-Pivaloylhydroxylamine trifluoromethanesulfonate, the publication is Journal of the American Chemical Society (2018), 140(1), 135-138, database is CAplus and MEDLINE.
¦Ã,¦Ä-Unsaturated N-pivaloylhydroxamates such as H2C:CHCH2CH2CONHOCOt-Bu underwent iridium-catalyzed diamination of the alkene with exogenous secondary amines such as N-methylaniline at 21¡ã in hexafluoroisopropanol (HFIP) or 2,2,2-trifluoroethanol (TFE) to yield either ¦Ã-(aminomethyl)-¦Ã-lactams such as I or ¦Ã-amino-¦Ä-lactams such as II regioselectively. Using the iridium complex of a (trifluoromethylphenyl)tetramethylcyclopentadiene as catalyst allowed ¦Á-substituted-¦Ã,¦Ä-unsaturated amides to be regioselectively and diastereoselective diaminated to cis-¦Ã-amino-¦Ä-lactams. On the basis of of mechanistic experiments, the relative rates of Ir(V)-nitrenoid formation and attack on the amido-Ir-coordinated alkene by the exogenous amine are proposed to determine the reaction selectivity.
Journal of the American Chemical Society published new progress about 1293990-73-4. 1293990-73-4 belongs to catalysis-chemistry, auxiliary class Aliphatic Chain, name is O-Pivaloylhydroxylamine trifluoromethanesulfonate, and the molecular formula is C6H12F3NO5S, Safety of O-Pivaloylhydroxylamine trifluoromethanesulfonate.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia