Watanabe, Hiroyuki published the artcileSynthesis and biological evaluation of radioiodinated 3-phenylcoumarin derivatives targeting myelin in multiple sclerosis, Product Details of C8H7NO4, the publication is Bioorganic & Medicinal Chemistry Letters (2020), 30(24), 127562, database is CAplus and MEDLINE.
Myelin is a lipid multilayer involved in the rate of nerve transmission, and its loss is a pathol. feature of multiple sclerosis in brains. Since in vivo imaging of myelin may be useful for drug development, early diagnosis, and monitoring the disease stage, the authors designed, synthesized, and evaluated eight novel radioiodinated 3-phenylcoumarin derivatives as imaging probes targeting myelin. In the biodistribution study using normal mice, all compounds displayed sufficient brain uptake, ranging from 2.5 to 5.0% ID/g, at 2 min postinjection. On ex vivo autoradiog., 6-[125I]- and 7-[125I]-labeled (dimethylaminophenyl)coumarins showed high binding affinity for myelin in the normal mouse brain. In addition, the radioactivity accumulation of the 7-[125I]-labeled (dimethylaminophenyl)coumarin in the white matter of the spinal cord in the exptl. autoimmune encephalomyelitis mice was lower than that in naive mice. These results suggest that a 7-[123I]-labeled (dimethylaminophenyl)coumarin shows potential as a single photon emission computed tomog. probe targeting myelin.
Bioorganic & Medicinal Chemistry Letters published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C6H13I, Product Details of C8H7NO4.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia