Shechter, Yoram’s team published research in Bioconjugate Chemistry in 23 | CAS: 10517-44-9

Bioconjugate Chemistry published new progress about 10517-44-9. 10517-44-9 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is Propane-1,3-diamine dihydrochloride, and the molecular formula is C20H28B2O4S2, Name: Propane-1,3-diamine dihydrochloride.

Shechter, Yoram published the artcileNewly Designed Modifier Prolongs the Action of Short-Lived Peptides and Proteins by Allowing Their Binding to Serum Albumin, Name: Propane-1,3-diamine dihydrochloride, the publication is Bioconjugate Chemistry (2012), 23(8), 1577-1586, database is CAplus and MEDLINE.

We found that human serum albumin (HSA) contains a single binding domain for derivatives of long-chain fatty acid (LCFA)-like mols. in which the carboxylate is replaced by sulfonate. Accordingly, we have synthesized 16-sulfo-hexadecanoic acid-N-hydroxysuccinimide ester [HO3S-(CH2)15-CONHS], an agent that reacts selectively with the amino side chains of peptides and proteins. A macromol. containing a single 16-sulfohexadecanoate moiety associating with albumin with a Ka value of 0.83¡À0.08¡Á106 M-1, a sufficient affinity to extend the actions in vivo of such short-lived peptides and proteins. S.c. administration of insulin-NHCO-(CH2)15-SO3– into mice facilitated a glucose-lowering effect 4.3 times in duration and 6.6 times in area under the curve (AUC) as compared to an in vitro equipotent amount of Zn2+-free insulin. Similarly, s.c. and i.v. administration of exendin-4-NHCO-(CH2)15-SO3– to mice yielded prolonged and stable reduction in glucose level, 5-9-fold longer than that of exendin-4. Also, a single s.c. administration of human interferon-¦Á2-[NH-CO-(CH2)15-SO3–]3 to mice yielded circulating antiviral activity over a period of 40 h. In conclusion, a simple, hydrophilic reagent has been engineered, synthesized, and studied. Its linkage to peptides and proteins in a mono-modified fashion yielded hydrophilic, prolonged acting derivatives, due to their acquired ability to associate with serum albumin after administration.

Bioconjugate Chemistry published new progress about 10517-44-9. 10517-44-9 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is Propane-1,3-diamine dihydrochloride, and the molecular formula is C20H28B2O4S2, Name: Propane-1,3-diamine dihydrochloride.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia