Tacke, Reinhold published the artcileSyntheses and Pharmacological Properties of the Histaminic H1 Antagonists Sila-terfenadine-A, Sila-terfenadine-B, Disila-terfenadine, and Sila-fexofenadine: A Study on C/Si Bioisosterism, Formula: C12H10F2Si, the publication is Organometallics (2004), 23(21), 4915-4923, database is CAplus.
Sila-substitution (C/Si exchange) of one or both of the two quaternary carbon atoms of the histaminic H1 antagonist terfenadine (1a) leads to sila-terfenadine-A (1b; R3COH ¡ú R3SiOH), sila-terfenadine-B (1c; R4C ¡ú R4Si), or disila-terfenadine (1d; R3COH ¡ú R3SiOH, R4C ¡ú R4Si). Sila-substitution of the quaternary carbon atom of the histaminic H1 antagonist fexofenadine (2a) affords sila-fexofenadine (2b; R3COH ¡ú R3SiOH). The silicon compounds were synthesized in multistep syntheses, and the identities of these compounds and their precursors were established by elemental analyses and multinuclear NMR studies. Some of the precursors were addnl. characterized by single-crystal x-ray diffraction. The pharmacol. profiles of silicon compounds were assessed across a range of histaminic receptor binding assays (radioligand binding studies at histamine central H1, peripheral H1, H2, and H3 receptors). The silicon compounds, within exptl. error, exhibited an affinity and selectivity profile similar to their corresponding carbon analogs.
Organometallics published new progress about 312-40-3. 312-40-3 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Difluorodiphenylsilane, and the molecular formula is C3H6F3N, Formula: C12H10F2Si.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia