Kim, Dong Wook published the artcileA New Class of SN2 Reactions Catalyzed by Protic Solvents: Facile Fluorination for Isotopic Labeling of Diagnostic Molecules, HPLC of Formula: 17351-62-1, the publication is Journal of the American Chemical Society (2006), 128(50), 16394-16397, database is CAplus and MEDLINE.
Aprotic solvents are usually preferred for the SN2 reactions, because nucleophilicity and hence SN2 reactivity are severely retarded by the influence of the partial pos. charge of protic solvents. In this work, we introduce a remarkable effect of using tertiary alcs. as a reaction medium for nucleophilic fluorination with alkali metal fluorides. In this novel synthetic method, the nonpolar protic tert-alc. enhances the nucleophilicity of the fluoride ion dramatically in the absence of any kind of catalyst, greatly increasing the rate of the nucleophilic fluorination and reducing formation of byproducts (such as alkenes, alcs., or ethers) compared with conventional methods using dipolar aprotic solvents. The great efficacy of this method is a particular advantage in labeling radiopharmaceuticals with [18F]fluorine (t1/2 = 110 min) for positron emission tomog. (PET) imaging, and it is illustrated by the synthesis of four [18F]fluoride-radiolabeled mol. imaging probes – [18F]FDG, [18F]FLT, [18F]FP-CIT, and [18F]FMISO – in high yield and purity and in shorter times compared to conventional syntheses.
Journal of the American Chemical Society published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C17H37NO3, HPLC of Formula: 17351-62-1.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia