Lee, Sumin published the artcileDirect Regio- and Diastereoselective Synthesis of ¦Ä-Lactams from Acrylamides and Unactivated Alkenes Initiated by RhIII-Catalyzed C-H Activation, Formula: C6H12F3NO5S, the publication is Angewandte Chemie, International Edition (2020), 59(12), 4965-4969, database is CAplus and MEDLINE.
Here a RhIII-catalyzed regio- and diastereoselective synthesis of ¦Ä-lactams such as I [R = Me, F, Bn, etc.; R1 = Me, cyclopentyl, Bn, etc.; R2 = H; R1R2 = (CH2)3, (CH2)2CH=CH, (CH2)6, etc.] and their regioisomers I [R = Me, F, Bn, etc.; R1 = H; R2 = Me, cyclopentyl, Bn, etc.] from readily available acrylamide derivatives and unactivated alkenes was reported. The regioselectivity of the reaction with unactivated terminal alkene was significantly improved by using Cpt ligand on the RhIII catalyst. The synthetic utility of the reaction was demonstrated by the preparation of a potential drug candidate containing a trisubstituted piperidine moiety. Mechanistic studies showed that the reversibility of the C-H activation depends on the choice of Cp ligand on the RhIII catalyst. The irreversible C-H activation was observed and becomes turnover-limiting with [CptRhCl2]2 as catalyst.
Angewandte Chemie, International Edition published new progress about 1293990-73-4. 1293990-73-4 belongs to catalysis-chemistry, auxiliary class Aliphatic Chain, name is O-Pivaloylhydroxylamine trifluoromethanesulfonate, and the molecular formula is C6H12F3NO5S, Formula: C6H12F3NO5S.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia