Yu, Zhiyi published the artcileDesign, synthesis and in vitro antibacterial/antifungal evaluation of novel 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)quinoline-3-carboxylic acid derivatives, Application In Synthesis of 1798-04-5, the publication is European Journal of Medicinal Chemistry (2009), 44(11), 4726-4733, database is CAplus and MEDLINE.
A series of 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)quinoline-3-carboxylic acid (norfloxacin) derivatives I (R = 2-furanyl, 3-pyridinyl, 2-ClC6H4OCH2, etc.) were prepared according to the principle of combining bioactive substructures, and tested for activity against five plant pathogenic bacteria and three fungi in vitro. The preliminary bioassays indicated that almost all the synthesized target compounds retained the antibacterial activities of norfloxacin and had some antifungal activities as seen with carboxamide compounds The activities of compounds I (R = 2-furanyl, Ph) against Xanthomonas oryzae were better than norfloxacin and all tested compounds had better antibacterial activities as compared to the agricultural streptomycin sulfate (a com. bactericide) against X. oryzae, Xanthomonas axonopodis and Erwinia aroideae. Addnl., compounds I [R = (E)-2-(5-methylfuran-2-yl)ethenyl, (E)-4-MeOC6H4CH:CH] displayed good antifungal activities against Rhizoctonia solani and their inhibition of growth reached 83% and 94% resp. at the concentration of 200 mg/L.
European Journal of Medicinal Chemistry published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C10H18O, Application In Synthesis of 1798-04-5.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia