Komoda, Kazuki published the artcileSolvent-Promoted Catalyst-Free Nucleophilic Fluoroalkylation of Aldehydes, Recommanded Product: Trimethyl(perfluorophenyl)silane, the publication is ChemistrySelect (2019), 4(8), 2374-2378, database is CAplus.
Fluoroalkyl silanes are useful building blocks for nucleophilic introduction of fluoroalkyl groups into organic mols. In general, fluoroalkyl silanes per se are stable compounds, but they are amenable to reactions as fluoroalkyl anion equivalent in the presence of base such as fluoride ion. Usually, KF acts as a good catalyst for nucleophilic fluoroalkylation of carbonyl compounds To avoid the use of hygroscopic fluoride salts, we have developed a convenient catalyst-free method for nucleophilic fluoroalkylation of aldehydes and ketones by the use of fluoroalkyl silanes. Trifluoromethyl(trimethyl)silane (Me3Si-CF3), and other fluoroalkyl silanes (Me3Si-Rf) underwent solvent-promoted nucleophilic addition to aldehydes smoothly to give fluoroalkylated alcs. in good yields. In the present reactions, the use of polar solvents such as DMSO, DMF or NMP is essential to the formation of 1,2-adducts.
ChemistrySelect published new progress about 1206-46-8. 1206-46-8 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Trimethyl(perfluorophenyl)silane, and the molecular formula is C9H9F5Si, Recommanded Product: Trimethyl(perfluorophenyl)silane.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia