Keane, P. E. published the artcileThe effects of analogs of valproic acid on seizures induced by pentylenetetrazol and GABA content in brain of mice, Computed Properties of 3115-28-4, the publication is Neuropharmacology (1983), 22(7), 875-9, database is CAplus and MEDLINE.
The effect of valproic?acid??[99-66-1] and 10 analogs (7 branched and 3 nonbranched) was studied on the content of ¦Ã-aminobutyric?acid (GABA) [56-12-2] in the brain of mice and on seizures induced by pentylenetetrazol. All 8 branched fatty acids protected against seizures, but the 3 nonbranched acids were inactive. A correlation was observed between side-chain length and anticonvulsant potency. However, sedative and toxic phenomena became apparent with longer chain lengths. The 3 nonbranched fatty acids did not alter levels of GABA in brain, but there was a correlation between anticonvulsant activity and increased brain GABA levels for the 8 branched fatty acids. Despite this correlation, one branched analog, 2-ethylbutyric?acid??[88-09-5], possessed anticonvulsant activity but did not increase the content of GABA in brain.
Neuropharmacology published new progress about 3115-28-4. 3115-28-4 belongs to catalysis-chemistry, auxiliary class Aliphatic Chain, name is 2-Butylhexanoic acid, and the molecular formula is C10H20O2, Computed Properties of 3115-28-4.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia