Nguyen, Dat P. published the artcileScope and limitations of reductive amination catalyzed by half-sandwich iridium complexes under mild reaction conditions, Formula: C10H10O3, the publication is Tetrahedron Letters (2020), 61(32), 152196, database is CAplus and MEDLINE.
The conversion of aldehydes and ketones RC(O)R1 (R = Ph, thiophen-2-yl, 4-bromophenyl, etc.; R1 = H, Me, CF3, Ph), 9H-fluoren-9-one to 1¡ã amines RCH(NH2)R1 could be promoted by half-sandwich iridium complexes using ammonium formate as both the nitrogen and hydride source. To optimize this method for green chem. synthesis, various carbonyl substrates in common polar solvents at physiol. temperature (37¡ãC) and ambient pressure were tested. The excellent selectivity for the amine over alc./amide RCH(OH)R1/RCH(R1)NHCHO products could be achieved for a broad assortment of carbonyl-containing compounds in methanol. In aqueous media, selective reduction of carbonyls to 1¡ã amines was achieved in the absence of acids. Unfortunately, at Ir catalyst concentrations of <1 mM in water, reductive amination efficiency dropped significantly, which suggest that this catalytic methodol. might be not suitable for aqueous applications where very low catalyst concentration is required (e.g., inside living cells).
Tetrahedron Letters published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C10H10O3, Formula: C10H10O3.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia