Scott, Jason A. published the artcileOptimization of a Pyrimidinone Series for Selective Inhibition of Ca2+/Calmodulin-Stimulated Adenylyl Cyclase 1 Activity for the Treatment of Chronic Pain, Product Details of C8H8O2, the publication is Journal of Medicinal Chemistry (2022), 65(6), 4667-4686, database is CAplus and MEDLINE.
Adenylyl cyclase type 1 (AC1) is involved in signaling for chronic pain sensitization in the central nervous system and is an emerging target for the treatment of chronic pain. AC1 and a closely related isoform AC8 are also implicated to have roles in learning and memory signaling processes. Our team has carried out cellular screening for inhibitors of AC1 yielding a pyrazolyl-pyrimidinone scaffold with low micromolar potency against AC1 and selectivity vs. AC8. Structure-activity relationship (SAR) studies led to analogs with cellular IC50 values as low as 0.25 ¦ÌM, selectivity vs. AC8 and other AC isoforms as well as other common neurol. targets. A representative analog displayed modest antiallodynic effects in a mouse model of inflammatory pain. This series represents the most potent and selective inhibitors of Ca2+/calmodulin-stimulated AC1 activity to date with improved drug-like physicochem. properties making them potential lead compounds for the treatment of inflammatory pain.
Journal of Medicinal Chemistry published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C14H15BF3NO2, Product Details of C8H8O2.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia