Koch, Bjoern E. V. published the artcileA quantitative in vivo assay for craniofacial developmental toxicity of histone deacetylases, Application of 2-Butylhexanoic acid, the publication is Toxicology Letters (2021), 20-25, database is CAplus and MEDLINE.
Many bony features of the face develop from endochondral ossification of preexisting collagen-rich cartilage structures. The proper development of these cartilage structures is essential to the morphol. formation of the face. The developmental programs governing the formation of the pre-bone facial cartilages are sensitive to chem. compounds that disturb histone acetylation patterns and chromatin structure. We have taken advantage of this fact to develop a quant. morphol. assay of craniofacial developmental toxicity based on the distortion and deterioration of facial cartilage structures in zebrafish larvae upon exposure to increasing concentrations of several well-described histone deacetylase inhibitors. In this assay, we measure the angle formed by the developing ceratohyal bone as a precise, sensitive and quant. proxy for the overall developmental status of facial cartilages. Using the well-established developmental toxicant and histone deacetylase-inhibiting compound valproic acid along with 12 structurally related compounds, we demonstrate the applicability of the ceratohyal angle assay to investigate structure-activity relationships.
Toxicology Letters published new progress about 3115-28-4. 3115-28-4 belongs to catalysis-chemistry, auxiliary class Aliphatic Chain, name is 2-Butylhexanoic acid, and the molecular formula is C10H20O2, Application of 2-Butylhexanoic acid.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia