Alsabeh, Pamela G. published the artcileAddressing Challenges in Palladium-Catalyzed Cross-Couplings of Aryl Mesylates: Monoarylation of Ketones and Primary Alkyl Amines, HPLC of Formula: 1237588-12-3, the publication is Angewandte Chemie, International Edition (2013), 52(28), 7242-7246, database is CAplus and MEDLINE.
The first examples of ketone mono-¦Á-arylation using aryl mesylates are disclosed and the amination of these inexpensive phenol derivatives with primary aliphatic amines have been successfully demonstrated. The [{Pd(cinnamyl)Cl}2]/Mor-DalPhos catalyst system allowed a range of substituted aryl mesylates to be coupled with both cyclic and acyclic dialkyl ketones, including acetone, which is normally a challenging reagent in mono-¦Á- arylation chem. Applying these optimized ketone ¦Á-arylation conditions to Buchwald-Hartwig amination enabled the mono-N-arylation of primary and secondary aliphatic amines, including methylamine, by employing aryl mesylates featuring electron-donating or electron-withdrawing functionality, ortho-substitution, as well as base-sensitive groups. The amination protocol displayed chemoselectivity, thus favoring cross-coupling of the primary amine in each case.
Angewandte Chemie, International Edition published new progress about 1237588-12-3. 1237588-12-3 belongs to catalysis-chemistry, auxiliary class Mono-phosphine Ligands, name is 4-(2-(Di(adamantan-1-yl)phosphino)phenyl)morpholine, and the molecular formula is C30H42NOP, HPLC of Formula: 1237588-12-3.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia