Liao, Daohong published the artcileNecrosulfonamide inhibits necroptosis by selectively targeting the mixed lineage kinase domain-like protein, Safety of (E)-3-(3-Nitrophenyl)acrylic acid, the publication is MedChemComm (2014), 5(3), 333-337, database is CAplus.
Through high-throughput screening of 200 000 compounds and subsequent structure-activity relationship (SAR) studies we identified necrosulfonamide (NSA) as a potent small mol. inhibitor for necroptosis, induced by a combination of TNF-a, Smac mimetic, and z-VAD-fmk (T/S/Z). Applying a forward chem. genetic approach, we utilized an NSA based chem. probe to further reveal that NSA selectively targeted the Mixed Lineage Kinase Domain-like Protein (MLKL) to block the necrosome formation.
MedChemComm published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, Safety of (E)-3-(3-Nitrophenyl)acrylic acid.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia