Yang, Xinglin published the artcileAuxiliary-assisted palladium-catalyzed halogenation of unactivated C(sp3)-H bonds at room temperature, Application In Synthesis of 1949-41-3, the publication is Chemical Communications (Cambridge, United Kingdom) (2016), 52(38), 6423-6426, database is CAplus and MEDLINE.
The direct transformation of unactivated C(sp3)-H bonds into C-halogen bonds was achieved by palladium catalysis at room temperature with good functional group tolerance. Some drugs and natural products were readily modified by this method. Merged with substitution reaction, newly formed C-X bonds can be transformed into diverse C-O, C-S, C-C and C-N bonds. A preliminary mechanism study demonstrates that solvent is crucial for C-H activation and the C-H activation step is involved in the rate-limiting step. An isolated Pd(II) intermediate can be transformed into a halogenated product with the retention of conformation which suggests that concerted reductive elimination from Pd(II) to form a C-X bond was favored.
Chemical Communications (Cambridge, United Kingdom) published new progress about 1949-41-3. 1949-41-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene, name is 2-Methyl-4-phenylbutanoic acid, and the molecular formula is C23H20BN, Application In Synthesis of 1949-41-3.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia