Otsuki, Makoto published the artcileBeneficial effects of the synthetic trypsin inhibitor camostate in cerulein-induced acute pancreatitis in rats, COA of Formula: C17H19N3O7S, the publication is Digestive Diseases and Sciences (1990), 35(2), 242-50, database is CAplus and MEDLINE.
The therapeutic effect and the mechanism of action of the synthetic trypsin inhibitor camostate were studied in a rat model of acute interstitial pancreatitis induced by caerulein. Rats with acute pancreatitis were given either 100 mg/kg body weight camostate or water via an orogastric tube 30 min after the caerulein injection. The elevation of serum amylase activity was reduced by camostate treatment and the peak value was seen 1 h earlier than that observed in the control group. Camostate also inhibited the reduction in pancreatic content of lipase and amylase seen during exptl. pancreatitis. These effects were accompanied by alleviation of the histol. signs of acute pancreatitis such as cellular infiltration and acinar cell vacuolization. After oral administration, camostate and its metabolite were absorbed from the intestine and were detectable in plasma for >6 h in concentrations high enough to have antiprotease activity. In addition, camostate in the duodenum was able to increase pancreatic juice flow and protein output and to stimulate endogenous secretin release. Thus, oral administration of camostate reduces the severity of caerulein-induced acute pancreatitis by releasing endogenous secretin and by its antiprotease activity.
Digestive Diseases and Sciences published new progress about 71079-09-9. 71079-09-9 belongs to catalysis-chemistry, auxiliary class Salt,Carboxylic acid,Carbamidine,Amine,Benzene,Ester,Protease,Ser/Thr Protease, name is 2-(4-((4-Guanidinobenzoyl)oxy)phenyl)acetic acid methanesulfonic acid salt, and the molecular formula is C17H19N3O7S, COA of Formula: C17H19N3O7S.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia