Fujito, Hiroshi published the artcileA study of efficient preparation of triethylenetetramine dihydrochloride for the treatment of Wilson’s disease and hygroscopicity of its capsule, Synthetic Route of 38260-01-4, the publication is Yakuzaigaku (1990), 50(4), 402-8, database is CAplus.
Triethylenetetramine-2HCl (I) for the treatment of Wilson’s disease is generally prepared by the reaction of triethylenetetramine (trien) and concentrated HCl. Using this method, the yield of I was 46.2% and trien-4HCl was obtained in a 21.3% yield as a byproduct. On the other hand, I was obtained in a 88.5% yield without formation of trien-4HCl by the reaction of trien and HCl gas in absolute EtOH. Capsules packed with I could stock for 30 days under 53% relative humidities of 25¡ã.
Yakuzaigaku published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C6H20Cl2N4, Synthetic Route of 38260-01-4.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia