Zhang, Fa published the artcileA viral insulin-like peptide is a natural competitive antagonist of the human IGF-1 receptor, Related Products of catalysis-chemistry, the publication is Molecular Metabolism (2021), 101316, database is CAplus and MEDLINE.
Natural sources of mol. diversity remain of utmost importance as a reservoir of proteins and peptides with unique biol. functions. We recently identified such a family of viral insulin-like peptides (VILPs). We sought to advance the chem. methods in synthesis to explore the structure-function relationship within these VILPs, and the mol. basis for differential biol. activities relative to human IGF-1 and insulin.Optimized chem. methods in synthesis were established for a set of VILPs and related analogs. These modified forms included the substitution of select VILP chains with those derived from human insulin and IGF-1. Each peptide was assessed in vitro for agonism and antagonism at the human insulin and the human insulin-like growth factor 1 receptor (IGF-1R).We report here that one of these VILPs, lymphocystis disease virus-1 (LCDV1)-VILP, has the unique property to be a potent and full antagonist of the IGF-1R. We demonstrate the coordinated importance of the B- and C-chains of the VILP in regulating this activity. Moreover, mutation of the glycine following the first cysteine in the B-chain of IGF-1 to serine, in concert with substitution to the connecting peptide of LCDV1-VILP, converted native IGF-1 to a high potency antagonist.The results reveal novel aspects in ligand-receptor interactions at the IGF-1 receptor and identify a set of antagonists of potential medicinal importance.
Molecular Metabolism published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C38H74Cl2N2O4, Related Products of catalysis-chemistry.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia