Briggs, Edward L. published the artcileSynthesis of Sulfonimidamides from Sulfenamides via an Alkoxy-amino-¦Ë6-sulfanenitrile Intermediate, COA of Formula: C10H15NS, the publication is Angewandte Chemie, International Edition (2019), 58(40), 14303-14310, database is CAplus and MEDLINE.
Sulfonimidamides are intriguing new motifs for medicinal and agrochem., and provide attractive bioisosteres for sulfonamides. However, there remain few operationally simple methods for their preparation Here, the synthesis of NH-sulfonimidamides is achieved directly from sulfenamides, themselves readily formed in one step from amines and disulfides. A highly chemoselective and one-pot NH and O transfer is developed, mediated by PhIO in iPrOH, using ammonium carbamate as the NH source, and in the presence of 1 equiv of acetic acid. A wide range of functional groups are tolerated under the developed reaction conditions, which also enables the functionalization of the antidepressants desipramine and fluoxetine and the preparation of an aza analog of the drug probenecid. The reaction is shown to proceed via different and concurrent mechanistic pathways, including the formation of novel S N sulfanenitrile species as intermediates. Several alkoxy-amino-¦Ë6-sulfanenitriles are prepared with different alcs., and shown to be alkylating agents to a range of nucleophiles.
Angewandte Chemie, International Edition published new progress about 19117-31-8. 19117-31-8 belongs to catalysis-chemistry, auxiliary class Oxidant, name is N-(tert-Butyl)-S-phenylthiohydroxylamine, and the molecular formula is C10H15NS, COA of Formula: C10H15NS.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia