Amin, Sk. Abdul published the artcileQuantitative activity-activity relationship (QAAR) driven design to develop hydroxamate derivatives of pentanoic acids as selective HDAC8 inhibitors: synthesis, biological evaluation and binding mode of interaction studies, COA of Formula: C8H7NO4, the publication is New Journal of Chemistry (2021), 45(37), 17149-17162, database is CAplus.
Histone deacetylase 8 (HDAC8) has been implicated as a potential drug target of many diseases including cancer. HDAC8 isoform selectivity over other class-I HDACs is a major concern nowadays. In this work, a series of pentanoic acid based hydroxamates with different substituted cap groups have been designed, synthesized, characterized, and screened against class-I HDACs. A quant. activity-activity relationship (QAAR) model was developed to design HDAC8 selective inhibitors. The designed compounds obtained through the mol. modeling study were synthesized, characterized, and their enzymic as well as cytotoxic activities were measured. Two compounds 2-(2-(2,4-Dichlorophenyl)acetamido)-N5-hydroxy-N1-pentylpentanediamide and 2-(2-(4-Chlorophenyl)acetamido)-N5-hydroxy-N1-pentylpentanediamide are found to be selective HDAC8 inhibitors over other class-I HDACs. These compounds possess better antiproliferative activities against some cancer cell lines. These observations are in agreement with the mol. docking studies for the binding mode of interactions. Further studies show that compounds 2-(2-(2,4-Dichlorophenyl)acetamido)-N5-hydroxy-N1-pentylpentanediamide and 2-(2-(4-Chlorophenyl)acetamido)-N5-hydroxy-N1-pentylpentanediamide induce significant cell growth arrest in the G2/M phase, indicating their anticancer potentials. In summary, our study confirms pentanoic acid based hydroxamate as selective HDAC8 inhibitors and two compounds 2-(2-(2,4-Dichlorophenyl)acetamido)-N5-hydroxy-N1-pentylpentanediamide and 2-(2-(4-Chlorophenyl)acetamido)-N5-hydroxy-N1-pentylpentanediamide may serve as lead mols. for further investigation.
New Journal of Chemistry published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C8H7NO4, COA of Formula: C8H7NO4.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia