Allott, Louis published the artcileRadiolabelling an 18F biologic via facile IEDDA “click” chemistry on the GE FASTLab platform, Recommanded Product: (4-(6-Methyl-1,2,4,5-tetrazin-3-yl)phenyl)methanamine trifluoroacetic acid, the publication is Reaction Chemistry & Engineering (2021), 6(6), 1070-1078, database is CAplus and MEDLINE.
The use of biologics in positron emission tomog. (PET) imaging is an important area of radiopharmaceutical development and new automated methods are required to facilitate their production We report an automated radiosynthesis method to produce a radiolabeled biol. via facile inverse electron demand Diels-Alder (IEDDA) “click” chem. on a single GE FASTLab cassette. We exemplified the method by producing a fluorine-18 radiolabeled interleukin-2 (IL2) radioconjugate from a trans-cyclooctene (TCO) modified IL2 precursor. The radioconjugate was produced using a fully automated radiosynthesis on a single FASTLab cassette in a decay-corrected radiochem. yield (RCY, d.c.) of 19.8 ± 2.6% in 110 min (from start of synthesis); the molar activity was 132.3 ± 14.6 GBq μmol-1. The in vitro uptake of [18F]TTCO-IL2 correlated with the differential receptor expression (CD25, CD122, CD132) in PC3, NK-92 and activated human PBMCs. The automated method may be adapted for the radiosynthesis of any TCO-modified protein via IEDDA chem.
Reaction Chemistry & Engineering published new progress about 1466420-02-9. 1466420-02-9 belongs to catalysis-chemistry, auxiliary class Copper-Free Click Chemistry,Tetrazine, name is (4-(6-Methyl-1,2,4,5-tetrazin-3-yl)phenyl)methanamine trifluoroacetic acid, and the molecular formula is C12H12F3N5O2, Recommanded Product: (4-(6-Methyl-1,2,4,5-tetrazin-3-yl)phenyl)methanamine trifluoroacetic acid.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia