Sterk, G. J. published the artcileStudies on histaminergic compounds. Part II. Synthesis and histamine H2-activity of dimaprit and some of its analogs, Synthetic Route of 6972-05-0, the publication is European Journal of Medicinal Chemistry (1984), 19(6), 545-50, database is CAplus.
By measuring the histamine H2-activity of dimaprit??[65119-89-3] at the isolated right atrium of the guinea-pig at pH 7.0 and 7.5 it was found that a monocation of dimaprit is the active species. Taking into account the necessary proton transfer it was concluded this is probably the monocation protonated at the amino group. Addnl., some dimaprit analogs were prepared and it was found that although some substituents at the amidino part of dimaprit and quaternization of the amino group gave an increase in the desired protonated form, any change in the structure of dimaprit resulted in an undetectable level of the histamine H2-activity.
European Journal of Medicinal Chemistry published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C8H14O2, Synthetic Route of 6972-05-0.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia