Sunitha, Pg published the artcileDevelopment of novel stability indicating RP-HPLC method for quantification of trientine hydrochloride and characterization of its degradation product by spectroscopic techniques, Application In Synthesis of 38260-01-4, the publication is Research Journal of Pharmaceutical, Biological and Chemical Sciences (2019), 10(3), 211-223, database is CAplus.
The present work reports the development of a novel stability indicating RP-HPLC method for the quantification of Trientine hydrochloride. The stability of Trientine hydrochloride was studied under different stress conditions recommended by ICH guidelines. Trientine contains amino group which makes it vulnerable to oxidative degradation The chromatog. separation of the drug and its degradation product was achieved in a Waters Reliant C8 column (250mm ¡Á 4.0mm ID, 4¦Ìm particle size) employing gradient elution using Acetronitrile and Ammonium formate buffer at pH 5.3 ¡À 0.05 (90:10) volume/volume, at a flow rate of 0.8mL/min and detection performed at 220 nm. The develop method has been validated as per ICH guidelines. Structural characterization and identification of the degradation product was done by LC-MS, 1H NMR, 13C NMR and IR spectroscopic studies. Toxicity prediction for the degradation product was achieved using the Software OSIRIS.
Research Journal of Pharmaceutical, Biological and Chemical Sciences published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C7H7ClN2S, Application In Synthesis of 38260-01-4.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia