Milosavljevic, Milutin M. published the artcileOptimization of the synthesis of N-alkyl and N,N-dialkyl thioureas from waste water containing ammonium thiocyanate, Computed Properties of 6972-05-0, the publication is Chemical Industry & Chemical Engineering Quarterly (2015), 21(4), 501-510, database is CAplus.
The optimized methods for N-alkyl and N,N-dialkyl substituted thioureas synthesis starting from ammonium thiocyanates, waste water constituent from the production of tetramethylthiuram monosulfide (TMTS), and alkyl amine, are presented in this work. Thioureas synthesis was developed in two ways: Method I – reaction of the thiocyanate and alkylamine in the presence of hydrochloric acid; Method II – reaction of the thiocyanate with benzoyl chloride following by amine addition in the first step, and base hydrolysis in the second step. The structure of the synthesized compounds was confirmed by IR, 1H- and 13C-NMR and MS instrumental methods, and purity was determined by high-performance liquid chromatog. method. It is shown that the proposed methods offer a high degree of conversion and purity of product, absence of byproducts and technol. applicability at industrial scale. Considering the importance of the tetramethylthiuram disulfide (TMTD) and TMTS as vulcanization accelerators as well as thiourea as the pharmacol. active compounds, it can be said that application of the optimized methods of thiourea synthesis will provide significant improvement in sustainable development and implementation of eco-friendly production technol. The described environmentally benign process of thioureas synthesis represents a suitable option to existing methods.
Chemical Industry & Chemical Engineering Quarterly published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, Computed Properties of 6972-05-0.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia