Iovkova, Ljuba published the artcilepara-functionalized aryl-di-tert-butylfluorosilanes as potential labeling synthons for 18F radiopharmaceuticals, Safety of Tetrabutylammonium hydrogencarbonate, the publication is Chemistry – A European Journal (2009), 15(9), 2140-2147, database is CAplus and MEDLINE.
The syntheses of the functionalized triorganofluorosilanes tBu2-(p-XC6H4)SiF (3a, X = SH; 4a, X = NCS; 4b, X = NCO; 5, X = NC4H2O2; 7, X = COOH; 8a, X = COONC4H4O2; 8b, X = COOC6F5) are reported. These compounds display potential as silicon-based fluoride acceptors (SiFAs). The mol. structures of compounds 5, 7, and 8a have been determined by single-crystal X-ray diffraction studies. With the exception of compounds 8a and 8b, all of the compounds could be 18F-labeled by isotopic exchange in good to high radiochem. yields (RCY) with good to excellent specific activities. As proof of applicability, the maleimido-functionalized SiFA derivative 5, which is specific for thiol groups, has been used for the labeling of rat serum albumin (RSA) that had been derivatized with 2-iminothiolane. The incorporation of [18F]5 into the derivatized RSA reached a maximum yield after 30 min at ambient temperature After purification, the [18F]RSA was evaluated in a healthy rat by means of ¦ÌPET and displayed an expedient in vivo stability over 180 min.
Chemistry – A European Journal published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C17H37NO3, Safety of Tetrabutylammonium hydrogencarbonate.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia