Gibbs, Kathleen’s team published research in Clinical Science and Molecular Medicine in 53 | CAS: 38260-01-4

Clinical Science and Molecular Medicine published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C6H20Cl2N4, HPLC of Formula: 38260-01-4.

Gibbs, Kathleen published the artcileThe effect of certain chelating compounds on the urinary excretion of copper by the rat: observations on their clinical significance, HPLC of Formula: 38260-01-4, the publication is Clinical Science and Molecular Medicine (1977), 53(4), 317-20, database is CAplus and MEDLINE.

Basal urine Cu excretion by rats was increased from 65.1 to 367.1 or 305.9 nmol/24 h by penicillamine [52-67-5] or triethylene tetramine-2HCl [38260-01-4] (100 mg orally), resp. Certain chelating agents depressed Cu excretion, e.g. 1,2,4-triazole [288-88-0] reduced excretion to 20.6 nmol/24 h, probably by forming insoluble chelates, rendering Cu unavailable for excretion at the glomerulus. The use of this screening procedure to assess rapidly the potential of chelating agents for the treatment of Wilson’s disease is discussed.

Clinical Science and Molecular Medicine published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C6H20Cl2N4, HPLC of Formula: 38260-01-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia