Rashidian, Mohammad published the artcileEnzyme-Mediated Modification of Single-Domain Antibodies for Imaging Modalities with Different Characteristics, Application In Synthesis of 1466420-02-9, the publication is Angewandte Chemie, International Edition (2016), 55(2), 528-533, database is CAplus and MEDLINE.
Antibodies are currently the fastest-growing class of therapeutics. Although naked antibodies proved valuable as pharmaceutical agents, they have some limitations, such as low tissue penetration and a long circulatory half-life. They have been conjugated to toxic payloads, PEGs, or radioisotopes to increase and optimize their therapeutic efficacy. Although nonspecific conjugation is suitable for most in vitro applications, it has become evident that site specifically modified antibodies may have advantages for in vivo applications. Herein the authors describe a novel approach in which the antibody fragment is tagged with two handles: one for the introduction of a fluorophore or 18F isotope, and the second for further modification of the fragment with a PEG moiety or a second antibody fragment to tune its circulatory half-life or its avidity. Such constructs, which recognize Class II MHC products and CD11b, showed high avidity and specificity. They were used to image cancers and could detect small tumors.
Angewandte Chemie, International Edition published new progress about 1466420-02-9. 1466420-02-9 belongs to catalysis-chemistry, auxiliary class Copper-Free Click Chemistry,Tetrazine, name is (4-(6-Methyl-1,2,4,5-tetrazin-3-yl)phenyl)methanamine trifluoroacetic acid, and the molecular formula is C12H12F3N5O2, Application In Synthesis of 1466420-02-9.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia