Cheng, Guilin published the artcileChemoenzymatic dynamic kinetic resolution of ¦Á-trifluoromethylated amines: influence of substitutions on the reversed stereoselectivity, Product Details of C3H6F3N, the publication is RSC Advances (2013), 3(25), 9820-9828, database is CAplus.
Enzymic resolution of ¦Á-trifluoromethylated amines via kinetic resolution (KR), dynamic kinetic resolution (DKR) employing Candida antarctica lipase B (CALB)-Pd/Al2O3, and a one-pot sequential process of KR/DKR/KR was investigated comparatively for the first time. Although CALB-catalyzed KR of ¦Á-trifluoromethylated amines with substituents of Me (1a), iso-Pr (1c), Ph (1d) and benzyl group (1e) can provide good stereoselectivity factors E from 31 to >200, resp., DKR and sequential process of KR/DKR/KR possess better practical application potential because of the higher conversion (62%-84%) and the similar enantiomeric excesses (90%-99%). The enantio-preference and inversion for the ¦Á-trifluoromethylated amines displayed by CALB were observed and explained by docking modes. Namely, for 1,1,1-trifluoro-2-propylamine (1a), the product amide with R-configuration was obtained, and the enantio-preference was converted to S for the amines (1b-1e) with substituents larger than Me group. The catalysts recycle, and scale-up experiments were demonstrated successfully. All these results indicated the high efficiency and green feature of this enzymic process, and its application significance.
RSC Advances published new progress about 421-49-8. 421-49-8 belongs to catalysis-chemistry, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain, name is 1,1,1-Trifluoropropan-2-amine, and the molecular formula is C3H6F3N, Product Details of C3H6F3N.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia