Xiao, Guiying published the artcileNickel-Catalyzed Asymmetric Hydrogenation of ¦Ã-Keto Acids, Esters, and Amides to Chiral ¦Ã-Lactones and ¦Ã-Hydroxy Acid Derivatives, Recommanded Product: 3-Benzoylpropionicacid, the publication is Organic Letters (2022), 24(14), 2722-2727, database is CAplus and MEDLINE.
A highly efficient asym. hydrogenation of a series of ¦Ã-keto acid derivatives, including ¦Ã-keto acids RC(O)CH2CH2C(O)OH (R = Me, Ph, cyclopentyl, 3,4-dimethylphenyl, etc.), esters RC(O)CH2CH2C(O)OR1 (R1 = Me, Et, t-Bu), and amides RC(O)CH2CH2C(O)NR2R3 (R2 = H, Bn, iPr; R3 = H, iPr), using a Ni-(R,R)-QuinoxP* complex as the catalyst has been developed to afford chiral ¦Ã-hydroxy acid derivatives RCH(OH)CH2CH2C(O)OR1 and RCH(OH)CH2CH2C(O)NR2R3 with excellent enantioselectivities, up to 99.9% ee. This method provides not only an economical one-pot approach for the synthesis of chiral ¦Ã-lactones I but also access to (S)-norfluoxetine, an inhibitor of neural serotonin reuptake and an essential intermediate for pharmaceutical synthesis.
Organic Letters published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C6H3BrFNO, Recommanded Product: 3-Benzoylpropionicacid.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia