Jin, Wen Bin published the artcileBioisosteric investigation of ebselen: Synthesis and in vitro characterization of 1,2-benzisothiazol-3(2H)-one derivatives as potent New Delhi metallo-¦Â-lactamase inhibitors, Name: 2,2′-Dithiodibenzoic acid, the publication is Bioorganic Chemistry (2020), 103873, database is CAplus and MEDLINE.
In the present study, by employing the concept of bioisosteric replacement of the selenium moiety of ebselen, a small compound library of 2-substituted 1,2-benzisothiazol-3(2H)-ones, compounds I [R = 4-lCC6H4, 4-HOCH2C6H4, cyclohexyl, etc.] were designed, synthesized and evaluated their cytotoxicity and synergistic activity in combination with meropenem against the E. coli Tg1 (NDM-1) strain. The most promising compound I [R = 4-lCC6H4] demonstrated potent synergistic activity against a panel of clin. isolated NDM-1 pos. CRE strains with FICI as low as 0.09. Moreover, its IC50 value and inhibition mechanism were also confirmed by using the enzyme inhibition assay and the ESI-MS anal. resp. Importantly, compound I [R = 4-lCC6H4] has acceptable toxicity and is not a PAINS. Because of its structural simplicity and potent synergistic activity in combination with meropenem, we propose that compound 3a may be a promising meropenem adjuvant and a new series of such compounds may worth further investigations.
Bioorganic Chemistry published new progress about 119-80-2. 119-80-2 belongs to catalysis-chemistry, auxiliary class sulfides,Carboxylic acid,Benzene, name is 2,2′-Dithiodibenzoic acid, and the molecular formula is C14H10O4S2, Name: 2,2′-Dithiodibenzoic acid.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia