Zhuang, Zhe published the artcileLigand-Enabled ¦Â-C(sp3)-H Olefination of Free Carboxylic Acids, Application of 2-Methyl-4-phenylbutanoic acid, the publication is Journal of the American Chemical Society (2018), 140(32), 10363-10367, database is CAplus and MEDLINE.
An acetyl-protected aminoethyl Ph thioether has been developed to promote C(sp3)-H activation. Significant ligand enhancement is demonstrated by the realization of the first Pd(II)-catalyzed olefination of C(sp3)-H bonds of free carboxylic acids without using an auxiliary. Subsequent lactonization of the olefinated product via 1,4 addition provided exclusively monoselectivity in the presence of multiple ¦Â-C-H bonds. The product ¦Ã-lactone can be readily opened to give either the highly valuable ¦Â-olefinated or ¦Ã-hydroxylated aliphatic acids. Considering the challenges in developing Heck couplings using alkyl halides, this reaction offers a useful alternative.
Journal of the American Chemical Society published new progress about 1949-41-3. 1949-41-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene, name is 2-Methyl-4-phenylbutanoic acid, and the molecular formula is C7H8BFO2, Application of 2-Methyl-4-phenylbutanoic acid.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia