Lyu, Zhigang published the artcileSteric-free bioorthogonal labeling of acetylation substrates based on a fluorine-thiol displacement reaction, Recommanded Product: 2,4,6-Trimethoxybenzenethiol, the publication is Journal of the American Chemical Society (2021), 143(3), 1341-1347, database is CAplus and MEDLINE.
We have developed a novel bioorthogonal reaction that can selectively displace fluorine substitutions alpha to amide bonds. This fluorine-thiol displacement reaction (FTDR) allows for fluorinated cofactors or precursors to be utilized as chem. reporters, hijacking acetyltransferase-mediated acetylation both in vitro and in live cells, which cannot be achieved with azide- or alkyne-based chem. reporters. The fluoroacetamide labels can be further converted to biotin or fluorophore tags using FTDR, enabling the general detection and imaging of acetyl substrates. This strategy may lead to a steric-free labeling platform for substrate proteins, expanding our chem. toolbox for functional annotation of post-translational modifications in a systematic manner.
Journal of the American Chemical Society published new progress about 77189-99-2. 77189-99-2 belongs to catalysis-chemistry, auxiliary class Thiophenol,Benzene,Ether, name is 2,4,6-Trimethoxybenzenethiol, and the molecular formula is C9H12O3S, Recommanded Product: 2,4,6-Trimethoxybenzenethiol.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia