Zlatopolskiy, Boris D. published the artcileDiscovery of 7-[18F]Fluorotryptophan as a Novel Positron Emission Tomography (PET) Probe for the Visualization of Tryptophan Metabolism in Vivo, Quality Control of 17351-61-0, the publication is Journal of Medicinal Chemistry (2018), 61(1), 189-206, database is CAplus and MEDLINE.
Tryptophan and its metabolites are involved in different physiol. and pathophysiol. processes. Consequently, positron emission tomog. (PET) tracers addressing tryptophan metabolic pathways should allow the detection of different pathologies like neurol. disorders and cancer. Herein we report an efficient method for the preparation of fluorotryptophans labeled in different positions with 18F and their biol. evaluation. 4-7-[18F]Fluorotryptophans ([18F]FTrps) were prepared according to a modified protocol of alc.-enhanced Cu-mediated radiofluorination in 30-53% radiochem. yields. In vitro experiments demonstrated high cellular uptake of 4-7-[18F]FTrps in different tumor cell lines. 4, 5-, And 6-[18F]FTrps, although stable in vitro, suffered from rapid in vivo defluorination. In contrast, 7-[18F]FTrp demonstrated a high in vivo stability and enabled a clear delineation of serotonergic areas and melatonin-producing pineal gland in rat brains. Moreover 7-[18F]FTrp accumulated in different tumor xenografts in a chick embryo CAM model. Thus, 7-[18F]FTrp represents a highly promising PET probe for imaging of Trp metabolism
Journal of Medicinal Chemistry published new progress about 17351-61-0. 17351-61-0 belongs to catalysis-chemistry, auxiliary class Phase Transfer Catalyst, name is Tetraethylammonium hydrogencarbonate, and the molecular formula is C6H13I, Quality Control of 17351-61-0.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia