Laps, Shay published the artcileInsight on the order of regioselective ultrafast formation of disulfide bonds in (antimicrobial) peptides and miniproteins, Formula: C20H19NO4, the publication is Angewandte Chemie, International Edition (2021), 60(45), 24137-24143, database is CAplus and MEDLINE.
Disulfide-rich peptides and proteins are among the most fascinating bioactive mols. The difficulties associated with the preparation of these targets have prompted the development of various chem. strategies. Nevertheless, the production of these targets remains very challenging or elusive. Recently, we introduced a strategy for one-pot disulfide bond formation, tackling most of the previous limitations. However, the effect of the order of oxidation remained an underexplored issue. Herein we report on the complete synthetic flexibility of the approach with respect to the order of oxidation of three disulfide bonds in targets that lack the knot motif. In contrast, our study reveals an essential order of disulfide bond formation in the EETI-II knotted miniprotein. This synthetic strategy was applied for the synthesis of novel analogs of the plectasin antimicrobial peptide with enhanced activities against methicillin-resistant Staphylococcus aureus (MRSA), a notorious human pathogen.
Angewandte Chemie, International Edition published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C20H19NO4, Formula: C20H19NO4.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia