Carraz, Gilbert published the artcileTheory of the activity of the di-n-propylacetic acid structure, Category: catalysis-chemistry, the publication is Agressologie (1967), 8(1), 13-20, database is CAplus and MEDLINE.
I.p. injection of isopropylisovaleric acid (3,3,4-trimethylpentanoic acid) at a dose equimolar to that of dipropylacetic acid (I) (200 mg./kg.) was as potent an anticonvulsive compound as I when injected into mice 30 min. prior to a s.c. injection of pentetrazole; equimolar doses of diethylacetic, 2,2-dimethylbutyric, 2,2-dimethylpropionic, and dimethylacetic acids had 80, 80, 80, and 20%, resp., of the activity of I, while dibutylacetic, isovaleric, vinylacetic, isocrotonic, and tiglic acids, together with EtCOCO2H, PrCOCO2H, and BuCOCO2H were nonprotective. Modifications of the alkyl chain, therefore, determine anticonvulsive activity in this series. Rats were injected with 2, 5, 10, and 25 mg. hexobarbital/kg. on 4 days, resp., which abolished the sedative effect of a subsequent injection of 150 mg. hexobarbital/kg.; however, injection of 50 mg. Depamide (Pr2CHCONH2)/kg. with a 150 mg./kg. dose of barbiturate into hexobarbital-pretreated mice caused sedation, indicating interference by Depamide towards enzymic processes. I and Depamide (i.p. injection of 200 mg./kg.) both extended the survival of mice under anoxic conditions. I homologs may interfere with enzymic processes; since abnormal urinary organic acids were detected after administration of I to rats, the interference may be at the Krebs cycle.
Agressologie published new progress about 3115-28-4. 3115-28-4 belongs to catalysis-chemistry, auxiliary class Aliphatic Chain, name is 2-Butylhexanoic acid, and the molecular formula is C10H20O2, Category: catalysis-chemistry.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia