Raisfeld, Ilene H. published the artcileRole of terminal substituents in the pulmonary toxicity of bleomycins, Quality Control of 10517-44-9, the publication is Toxicology and Applied Pharmacology (1981), 57(3), 355-66, database is CAplus and MEDLINE.
Amines with structures identical to the chem. substituents X linked to the bithiazole rings of various bleomycins (I) were studied for their pulmonary toxicity in mice. Thus, intratracheally administered putrescine-2HCl [333-93-7], spermidine-3HCl [334-50-9], spermine-4HCl [306-67-2], histamine-HCl [56-92-8], 1,3-diaminopropane-HCl [10517-44-9], and agmatine sulfate [2482-00-0] produced dose-related lesions of pulmonary fibrosis and metaplasia indistinguishable from lesions produced by intact bleomycins. The high pulmonary toxicity of bleomycin A5 [11116-32-8] relative to bleomycin B2 [9060-10-0] corresponded to the changes produced by their resp. spermidine and agmatine substituents. An important role is suggested for the terminal substituent in bleomycin-induced lung injury.
Toxicology and Applied Pharmacology published new progress about 10517-44-9. 10517-44-9 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is Propane-1,3-diamine dihydrochloride, and the molecular formula is C3H12Cl2N2, Quality Control of 10517-44-9.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia