Uno, Taku published the artcileKidney dysfunction in Wilson disease, Quality Control of 38260-01-4, the publication is Biomedical Research on Trace Elements (1998), 9(2), 85-94, database is CAplus.
Forty-seven patients with Wilson disease were studied for their kidney dysfunction. Among them, 36 patients were not treated and 11 were treated. Over one-third of the patients revealed renal tubular abnormalities at first visit to our clinic. Such abnormalities could not explain the cause of hypouricemia in the fulminant and hemolytic anemia type of Wilson disease. Ten of 31 patients (32.3%) had nephrocalcinosis. These findings were almost completely improved following prolonged treatment with penicillamine or trientine hydrochloride. Significant microscopic hematuria was found in 21 of the 36 treated patients (58.3%) and proteinuria was found in 14 of these 36 patients (38.9%). Except for the fulminant and hemolytic anemia type of Wilson disease, dysmorphic urinary RBCs, granular and RBC casts were found on routine light microscopy in our study. These urinary findings suggest glomerular dysfunction. Besides the occurrence of local damage to the kidney or an irritant effect of copper on the glomeruli and renal tubules, we speculate that glomerular dysfunction due to liver cirrhosis should be considered, including for example, hepatic IgA glomerulonephritis.
Biomedical Research on Trace Elements published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C10H16Br3N, Quality Control of 38260-01-4.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia